Natriuretic Peptide Receptor (NPR)

Natriuretic Peptide Receptor; NPR; NPR-A; NPR-B; NPR-C

Natriuretic peptide receptors can be divided into three types: NPR-A, NPR-B (guanylate cyclase-A and guanylate cyclase-B) and NPR-C. All three receptors have an effect on biological second messengers. NPR-A and NPR-B are guanylate cyclase receptors, and their activation can lead to increased cGMP levels, while the activation of NPR-C can lead to the inhibition of adenylate cyclase activity and increased phospholipase C activity. Natriuretic peptide receptors play an important role in the regulation of blood pressure and cardiovascular homeostasis[1].
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